Sildenafil Helpful in Neurological Disorders

Sildenafil is the very efficient drug used against the male impotence. Sildenafil is the first drug that was discovered by the Pfizer in 1998. Sildenafil was studied by scientists at Pfizer for the hypertension and angina pectoris, but during the clinical trials it was noted that Sildenafil induced erections in the men. With the 100 mg dosage of the Sildenafil men were able to get the erections for about 4 to 6 hours. Thus, Pfizer marketed it as the erectile dysfunction drug. Sildenafil citrate was then approved by the Food and Drug Administration in United States as safe and efficient drug against erectile dysfunction. Sildenafil was named as the Viagra by the Pfizer and it soon became the great success in the US market. According to the latest study published in the American Neurological Journal, Sildenafil is fount to be helpful in the neurological disorders.

Sildenafil when taken in lower doses for about 3 to 4 weeks showed an astonishing result in the patients suffering with the Neurological disorders. In the study the 250 patients suffering with the one to these diseases participated---neurological disorders like Alzheimer's disease, Aphasia, Bell's palsy, Creutzfeldt-Jakob disease, epilepsy, encephalitis, Huntington's disease, Neuromuscular disorders, neuro-oncology, neuro-immunology, neuro-otology, pain, pediatric neurology, phobia, sleep disorders, Tourette syndrome, or Parkinson's disease. To all these men a lower dose of Sildenafil was given for 1 week and then the condition of these men was examined by the doctors. It was noted that 12 men got the relief from the neurological disorders. Then to the remaining men the dosage of Sildenafil was given 10 mg more than the last week’s concentration. During the second weeks trial 35 men suffering with neurological disorders found relief.

In the third week, the dose of Sildenafil was kept constant. At the end of third week, 43 more individuals felt a relief from the neurological disorders. Then in the 4th week, the Sildenafil dose was increased by 10 mg. Out of the remaining men 67 men felt relieved from the neurological disorders. Thus, 63% men out of 250 observed an improvement in their conditions with the low doses of the Sildenafil. It also favorably influences the nitric oxide-cyclic guanosine monophosphate pathways, which are involved in the pathogenesis of a number of neurological diseases. Its potential therapeutic role in the treatment of the neurological disorders mentioned above is still under preclinical investigation. Thus, preclinical and very limited clinical data suggest that Sildenafil may have therapeutic potential in selected neurological disorders.

Sildenafil citrate is basically a phosphodiesterase 5 inhibitor that improves the blood supply throughout the body. The main cause of the neurological disorders is the found to be the improper blood supply to the brain or to the certain parts of the brain. Sildenafil improves the blood supply to the brain by promoting the production of the enzymes that increase the blood supply to the brain. Thus, the brain gets the enough blood supply and neurological disorders are treated by Sildenafil. The nerves and veins in the brain are relaxed by the Sildenafil, thus the pain caused in the brain because of the neurological disorders is stopped. Sildenafil shows its effect in almost all the neurological disorders but the time required for the treatment may vary.

Sildenafil has a great record in treating the men suffering with the erectile dysfunction in men. All the men who used Sildenafil for the treatment of erectile dysfunction are satisfied with the results. But, still it is not approved by the FDA as the drug against the neurological disorders. Although Sildenafil shows some promise as a therapeutic agent in selected neurological disorders, well-designed clinical trials are needed before the agent can be recommended for use in any neurological disorder. So, you should you resist yourself from using Sildenafil for neurological disorders unless it gets approval fro the Food and Drug Administration.

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